Eucodis starts commercialization of tubulysin A and B

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Vienna, Austria, January 27th: EUCODIS Bioscience is glad to announce that it has teamed up with Tube Pharmaceuticals to bring the production of tubulysins to a commercial level. Tube Pharmaceuticals and EUCODIS now jointly produce and commercialize tubulysin A and B and other variants of this cytotoxic compound.

Tubulysins are isolated from the culture broth of strains of Archangium gephyra and Angiococcus disciformis, both members of a Gram negative, soil-dwelling group of bacteria known as myxobacteria. The production process has been up-scaled and tubulysin A and B are now produced by EUCODIS Bioscience.

The compounds bind to tubulin, the basic protein of microtubules, which play a structural role in the cell’s cytoskeleton and a functional role in mitosis. Tubulysin binding causes microtubules to depolymerize, leading to break-up of the cytoskeleton and driving the cell into apoptosis.

Tubulysins, and their synthetic derivatives, can be covalently conjugated to a wide variety of carrier molecules including antibodies, peptides or nanoparticles, and thereby offer the potential to target many types of cells and tissues. In certain drug-resistant cell lines, such as resistant ovarian cancer, tubulysin shows a greater potency profile than other toxins.

 

About Tube Pharmaceuticals GmBH:  www.tubepharma.de
Tube Pharmaceuticals GmbH, a Vienna-based start-up formed in 2011, is commercializing a natural products platform having its foundation in the discovery of tubulysin molecules. Tubulysins,  microtubule- disrupting agents and their synthetic derivatives, can be covalently conjugated to a wide variety of carrier molecules, and thereby offer the potential to target many types of cells and tissues. Tube is developing a polymer-tubulysin conjugate for solid tumors and has licensed the toxin for use in other conjugate therapeutics to selected partners.


>> More information: Tubulysins

>> More information: C-LiNK (CTAT) - Enzymatic Drug Conjugation

Tubulin skeleton of cancer cells disrupted by tubulysins

Picture kindly provided by Prof. G. Hoefle, Braunschweig, Germany